Innovations in analytical techniques and risk assessment frameworks have significantly advanced the field of environmental chemistry & toxicology, where the focus lies on tracing, identifying, and quantifying hazardous substances across air, water, soil, and biota. The discipline evaluates chemical fate, transformation pathways, and ecotoxicological impacts, shedding light on persistent organic pollutants, endocrine disruptors, and microplastics. New frontiers in exposomics and molecular toxicology are refining our understanding of chronic exposure effects on human health and ecosystems. Regulatory science increasingly draws upon findings from Environmental Chemistry & Toxicology to define safety thresholds and guide remediation priorities. Whether addressing legacy pollutants or emerging contaminants, this area remains pivotal in informing environmental risk governance and advancing chemical safety on a global scale.