Title : Personalized and Precision Medicine (PPM) as a unique healthcare model through Design-driven biotech and upgraded business marketing to secure the Planetary ecosystem, human healthcare and biosafety
Abstract:
A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). As we attempt to exit the Anthropocene and imagine a new, symbiotic way of existence, the ability to visualize the biological underpinnings of the personal, public, and planetary health continuum is becoming a remarkable asset. It has the potential to, at once, truly personalize healthcare, and at the same time undo the untenable status quo that otherwise maintains grotesque social inequities and the global spread of products that are unhealthy for person, place, and planet. Therefore, it is time to (re)claim the vital term clinical ecology (rooting from PPM-based ecosystems) - a label that once represented a fringe field focused on sick building syndrome.
Because of technological advances, particularly, PPM-based healthcare services, digitization increasingly influences health-related business models. IN this context, PPM is considered to be an emergent and complex phenomenon that encompasses several industries, has the potential to impact both private and public organizations as well as citizens worldwide but surprisingly has not yet been studied from an ecosystem perspective.
In terms of PPM-guided trends, design-driven biotech and synthetic biology are rapidly emerging interdisciplinary field that is primarily built upon foundational advances in systems biology combined with engineering design. The field considers living systems as programmable at the genetic level and defined by the development of new platform technologies being interacted with the microenvironment. Originally rooted in innovative disciplines, biodesign has transcended into diverse bioindustries, including biotechnology. In the context of biotech product development, biodesign thinking offers a fresh perspective to address complex scientific, technological, and societal challenges. By focusing on the needs of end-users, whether they are healthcare professionals, environment-related experts, food designers, biodesign thinking creates a framework to drive innovation and generate meaningful solutions.
As the demand for medical treatment surges - fuelled by an ageing population, sedentary lifestyles, and breakthroughs in drug development and pharmaceutical technologies - the healthcare sector’s environmental impact continues to escalate. Taking an eco-conscious approach to the design of the bioproducts and bioservices gives special consideration to the environmental impacts of the latter over its entire lifecycle without sacrificing safety or regulatory compliance.
The social and behavioral sciences play a dual role in PPM to get integrated with the environmental factors in one and the new entity. The first is integrating information on lifestyle and exposures – demographics, environment, social support, sleep, exercise habits and the like – into a comprehensive picture of each individual’s health. The second role is studying how patients and practitioners interact with emerging PPM approaches and technologies, to gain understanding that will lead to better policies and best practices.
The global PPM-related market is experiencing unprecedented growth, driven by advancements in genomic technologies, increased focus on personalized healthcare, and the rising prevalence of chronic diseases. PPM, which tailors treatment based on individual genetic, environmental, and lifestyle factors, is revolutionizing the healthcare landscape. As healthcare costs skyrocket and patient demographics become increasingly diverse, PPM emerges as a crucial, targeted approach to the prevention, predictive diagnosis, and treatment of diseases. By leveraging individual genetic information, lifestyle factors, and environmental insights, PPM disrupts the traditional one-size-fits-all model of healthcare delivery, promising unprecedented personalization and efficacy. In this context, the design-driven and market-guided biotech industry has been a driving force behind groundbreaking innovations that have revolutionized healthcare, agriculture, and environmental sustainability. A global revolution has been in the making in planetary ecosystem, human healthcare and biosafety with convergence of
- digital technologies;
- multi-OMICS Big Data integration;
- growing interest in the “variability science” of PPM and
- planetary health scholarship that both scales up and integrates biological, clinical, and ecological contexts of health and disease.
By engaging the above-mentioned Big Data – and the interventions that are based upon them, design-supported PPM offers promise of highly individualized manipulations to prevent illness, optimization of structure and function, and concomitantly, the potential for (mis) using data to incur harm. PPM and design-driven biotech are still in its preliminary stages, but they have the potential to reshape the healthcare sector and the interactions of health with the environment. As we succeed to unravel the puzzle of the latter, we are at the cusp of a revolutionizing healthcare future.
